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For the acute treatment of migraine attacks with or without aura in adults
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About ZAVZPRET
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What is ZAVZPRET® (zavegepant)?
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ZAVZPRET is a prescription medicine used in adults for the acute treatment of migraine attacks with or without aura. It's a nasal spray proven to treat migraine pain fast.*
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*Pain freedom was experienced in 2 hours, and some patients experienced pain relief in as little as 15 minutes.
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Fast action through the nose
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ZAVZPRET is rapidly absorbed in the nasal cavity, directly entering the bloodstream so it can get to work fast on migraine. One spray could provide up to 48 hours of migraine freedom.
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One spray to help get back to the day
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Freedom from pain at 2 hours† that lasted up to 48 hours‡
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Freedom from most bothersome symptom at 2 hours† and back to normal function in just 30 minutes§
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Pain relief in as little as 15 minutes in some patients‖
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See additional details below.
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Studies Have Shown
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†In 2 hours, ZAVZPRET:
- provided freedom from pain in 24% (n=147/623) of people taking ZAVZPRET vs 15% (n=96/646) taking the placebo
- provided freedom from most bothersome symptom (light sensitivity, sound sensitivity, or nausea) in 40% (n=247/623) of people taking ZAVZPRET vs 31% (n=201/646) taking the placebo
- provided pain relief in 59% (n=366/623) of people taking ZAVZPRET vs 50% (n=321/646) taking the placebo
- helped patients experience a return to normal function in 36% (n=204/570) of people taking ZAVZPRET vs 26% (n=152/593) taking the placebo
‡At 48 hours, ZAVZPRET:
- provided sustained pain freedom in 12% (n=77/623) of people taking ZAVZPRET vs 9% (n=56/646) taking the placebo
§At 30 minutes, ZAVZPRET:
- provided the ability to function normally in 11% (n=60/570) of people taking ZAVZPRET vs 6% (n=36/593) taking the placebo
‖In 15 minutes, ZAVZPRET:
- provided pain relief in 16% (n=99/623) of people taking ZAVZPRET vs 8% (n=52/646) taking the placebo
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ZAVZPRET is generally well tolerated
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In clinical studies, 18% of people temporarily experienced unusual taste after using ZAVZPRET. The most common side effects were unusual taste, nausea, nasal discomfort, and vomiting. Allergic reactions, including hives and swelling of the face, can occur after using ZAVZPRET. High blood pressure and a circulation problem called Raynaud's phenomenon may occur or worsen after taking ZAVZPRET. Call your healthcare provider or get emergency help if you have swelling of the face, mouth, tongue, or throat, trouble breathing, rash, and hives.
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ZAVZPRET was not associated with sedation or fatigue in clinical trials.
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Most side effects in clinical trials were mild or moderate.
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Tell your healthcare provider if you experience any bothersome side effects.
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“Being able to take ZAVZPRET was so helpful because I was able to feel the relief within about 30 minutes or so.”
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Carlene Forbes
Content creator and style curator who refuses to let migraine derail her day.
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Real ZAVZPRET patient
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Learn how to get a prescription
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