How to use zavzpret^™

IMPORTANT SAFETY INFORMATION

Do not use ZAVZPRET if you are allergic to ZAVZPRET or its ingredients.

Before you use ZAVZPRET, tell your healthcare provider (HCP) about all of your medical conditions, including if you

• have high blood pressure
• have circulation problems in your fingers and toes
• have liver or kidney problems
• are pregnant or plan to become pregnant
• are breastfeeding or plan to breastfeed

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

ZAVZPRET may cause serious side effects, including:

Allergic reactions, including hives and swelling of the face, can occur after you use ZAVZPRET. Call your HCP or get emergency help if you have swelling of the face, mouth, tongue, or throat or trouble breathing.

High blood pressure can worsen or occur after you take ZAVZPRET. Contact your HCP if you have an increase in blood pressure.

A circulation problem called Raynaud's phenomenon can worsen or occur after you take ZAVZPRET. This can lead to your fingers or toes feeling numb, cool, or painful, or changing color from pale, to blue, to red. Contact your HCP if these symptoms occur.

The most common side effects of ZAVZPRET include unusual taste, nausea, nasal discomfort, and vomiting. These are not the only possible side effects
of ZAVZPRET. Tell your HCP if you have any side effects.

You are encouraged to report adverse events related to Pfizer products by calling 1-800-438-1985 (U.S. only). If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly. Visit www.fda.gov/medwatch or call 1800FDA1088.