for use

If you have ZAVZPRET and are ready to use it, this video can help.

Transcript +

You’re here because of migraine. I know how difficult that can be, so. I’ll keep this short and sweet.

First things first, grab a tissue and clear your nose.

OK, you’re ready for ZAVZPRET. Remove one blister pack.

Be sure to check the expiration date on the blister pack.

Remove one device from the blister pack.

And check the expiration date on the device.

Now don’t press anything just yet.

Hold the device upright with your thumb on the bottom and two fingers on either side of the nozzle, like I am. Remember, we’re not pressing the plunger yet.

With your other hand, gently press and close one of your nostrils. Continue breathing normally through your mouth.

Insert the nozzle into the open nostril as much as you comfortably can.

Be sure to keep your head level and upright and close your mouth.

Slowly breathe in through your nose as you firmly press the plunger up with your thumb to release the spray.

Just one spray in one nostril.

Have your head level and upright. Once all the spray is released, remove your finger and the device from your nostril.

Great, you’re almost done.

Now, relax, keep your head level, and gently breathe in through your nose and out through your mouth for 10-20 seconds.

If you feel a drip from your nose, that’s okay.

Gently sniff so you don’t lose any of the medication.

Well, that’s ZAVZPRET–just one spray in one nostril. All that’s left to do is discard the used device in the trash.

I’ll let you go now. If you need anything else, you know where to find us. Feel better soon.

Tips for managing a migraine attack

You can try to manage a migraine attack in the moment by:

  • Getting rest
  • Drinking water
  • Trying a cold or warm compress
  • Meditating (or searching for guided meditations)
  • Turning off screens
Hand Holding Water Bottle


ZAVZPRET™ (zavegepant) nasal spray is a prescription medicine used in adults for the acute treatment of migraine attacks with or without aura.

ZAVZPRET is not used to prevent migraine attacks. It is not known if ZAVZPRET is safe and effective in children.

Please see the full Prescribing Information and Patient Information, including Instructions for Use.


Do not use ZAVZPRET if you are allergic to ZAVZPRET or its ingredients.

Before you use ZAVZPRET, tell your healthcare provider about all of your medical conditions, including if you:

  • have kidney problems
  • have liver problems
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

ZAVZPRET may cause serious side effects. Allergic reactions, including hives and swelling of the face can occur after you use ZAVZPRET. Call your healthcare provider or get emergency help if you have swelling of the face, mouth, tongue, or throat or trouble breathing.

The most common side effects of ZAVZPRET include unusual taste, nausea, nasal discomfort, and vomiting. These are not the only possible side effects
of ZAVZPRET. Tell your healthcare provider if you have any side effects.